Prostasomes: extracellular vesicles from the prostate
نویسندگان
چکیده
منابع مشابه
Secretions from seminal vesicles lack characteristic markers for prostasomes
BACKGROUND Prostasomes are suggested to be produced in the prostate gland. Although biochemical studies support this, some immunohistochemical findings indicate that also the seminal vesicles could be a source of prostasomes. Therefore, we have compared the secretion of the vesicles with that of the prostate using biochemical and ultrastructural techniques. METHODS Ultracentrifuged pellets of...
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Accumulating data indicates that tumor-derived extracellular vesicles (EVs) are responsible for tumor-promoting effects. However, if tumor EVs also prepare the tumor-bearing organ for subsequent tumor growth, and if this effect is different in low and high malignant tumors is not thoroughly explored. Here we used orthotopic rat Dunning R-3327 prostate tumors to compare the role of EVs from fast...
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Extracellular vesicles, naturally released from all cell types including bacteria, are of great importance in medical microbiology due to transporting a variety of biomaterials, enzymes, and virulence factors, regulating immunity, and having roles in colonization and initiation of signaling pathways. These vesicles are also secreted from microbiota in the gastrointestinal tract and affect the h...
متن کاملThe Prostate StructuralHeterogeneityandProteinCompositionof Exosome-LikeVesicles (Prostasomes) in HumanSemen
BACKGROUND. Human seminal fluid contains small exosome-like vesicles called prostasomes. Prostasomes have been reported previously to play an important role in the process of fertilization by boosting survivability and motility of spermatozoa, in addition to modulating acrosomal reactivity. Prostasomes have also been reported to present with sizes varying from 50 to 500 nm and to have multilaye...
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New biomarkers are needed to improve the diagnosis of prostate cancer. Similarly to healthy cells, prostate epithelial cancer cells produce extracellular vesicles (prostasomes) that can be isolated from seminal fluid, urine, and blood. Prostasomes contain ubiquitously expressed and prostate-specific membrane and cytosolic proteins, as well as RNA. Both quantitative and qualitative changes in pr...
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ژورنال
عنوان ژورنال: REPRODUCTION
سال: 2014
ISSN: 1470-1626,1741-7899
DOI: 10.1530/rep-13-0358